Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 8/20 | 0.56 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14529605 | 0.88 | ITGB1 (0.53) | TSHRALDH1A1ITGB1ITGA4ITGB7 | |
| SCHEMBL5332792 | 0.87 | HSD11B1 (0.53) | ITGB1ITGA4ITGB7HSD11B1 | |
| SCHEMBL14529947 | 0.87 | HSD11B1 (0.53) | ITGB1ITGA4ITGB7HSD11B1 | |
| SCHEMBL14529616 | 0.86 | HSD11B1 (0.65) | HCRTR1HCRTR2ITGB1ITGA4ITGB7 | |
| SCHEMBL14529964 | 0.86 | HSD11B1 (0.65) | HCRTR1HCRTR2ITGB1ITGA4ITGB7 | |
| SCHEMBL5345940 | 0.85 | TSHR (0.62) | HCRTR1HCRTR2LMNATSHRALDH1A1 | |
| SCHEMBL5345936 | 0.85 | TSHR (0.62) | HCRTR1HCRTR2LMNATSHRALDH1A1 | |
| SCHEMBL5452294 | 0.83 | GAA (0.48) | HCRTR1HCRTR2LMNATSHRITGB1 | |
| SCHEMBL14529760 | 0.82 | HSD11B1 (0.61) | ITGB1ITGA4ITGB7HSD11B1 | |
| SCHEMBL5315648 | 0.82 | HSD11B1 (0.61) | ITGB1ITGA4ITGB7HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871208-B2 | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof | ABBVIE INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20110159005-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110159005-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF | HSD11B1, HSD17B1, HSD11B2 | HCRTR1 1437/4885HCRTR2 1477/4885LMNA 4087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.