Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345940 | 1.00 | TSHR (0.62) | TSHRMAPK1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14529605 | 0.88 | ITGB1 (0.53) | TSHRMAPK1ALDH1A1HSD11B1L3MBTL1 | |
| SCHEMBL12640491 | 0.85 | HCRTR1 (0.57) | TSHRALDH1A1HSD11B1HCRTR1HCRTR2 | |
| SCHEMBL14529774 | 0.83 | TSHR (0.57) | TSHRMAPK1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5332792 | 0.83 | HSD11B1 (0.53) | HSD11B1ITGB1ITGA4ITGB7 | |
| SCHEMBL14529947 | 0.83 | HSD11B1 (0.53) | HSD11B1ITGB1ITGA4ITGB7 | |
| SCHEMBL14529964 | 0.82 | HSD11B1 (0.65) | HSD11B1HCRTR1HCRTR2MMP1ITGB1 | |
| SCHEMBL14529616 | 0.82 | HSD11B1 (0.65) | HSD11B1HCRTR1HCRTR2MMP1ITGB1 | |
| SCHEMBL5452294 | 0.81 | GAA (0.48) | TSHRGAAHSD11B1HCRTR1HCRTR2 | |
| SCHEMBL5314816 | 0.76 | HSD11B1 (0.53) | HSD11B1HCRTR1HCRTR2ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057768-A2 | SULFONYL DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057768-A2 | SULFONYL DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |