Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.58 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61489 | 0.85 | SIGMAR1 (0.72) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL15744773 | 0.85 | KMT2A (0.62) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL13003507 | 0.83 | SIGMAR1 (0.57) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL15745866 | 0.83 | MEN1 (0.60) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL8223184 | 0.79 | PRKAA2 (0.54) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL61848 | 0.79 | TMEM97 (0.83) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL694949 | 0.79 | SIGMAR1 (0.82) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 | |
| SCHEMBL14115981 | 0.79 | SIGMAR1 (0.67) | SIGMAR1KMT2AKCNH2 | |
| SCHEMBL12642617 | 0.78 | ALDH1A1 (0.65) | SIGMAR1CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL62237 | 0.78 | DRD4 (0.76) | SIGMAR1TMEM97MCHR1SLC6A12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336125-A1 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | Janssen Pharmaceutica N.V. (BE) | 2011-06-22 | — | — | EP | disclosed |