Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.61 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15745866 | 0.88 | MEN1 (0.60) | KMT2AMEN1SIGMAR1TMEM97MCHR1 | |
| SCHEMBL14649115 | 0.86 | PRKAA2 (0.66) | KMT2AMEN1SIGMAR1TMEM97MCHR1 | |
| SCHEMBL12642632 | 0.85 | SIGMAR1 (0.59) | KMT2AMEN1SIGMAR1TMEM97MCHR1 | |
| SCHEMBL61848 | 0.82 | TMEM97 (0.83) | KMT2AMEN1SIGMAR1TMEM97MCHR1 | |
| SCHEMBL14100464 | 0.79 | SIGMAR1 (0.64) | KMT2ASIGMAR1MCHR1KDM4EDRD4 | |
| SCHEMBL12642482 | 0.79 | SIGMAR1 (0.72) | SIGMAR1 | |
| SCHEMBL14115981 | 0.79 | SIGMAR1 (0.67) | KMT2ASIGMAR1KCNH2DRD4 | |
| SCHEMBL694949 | 0.79 | SIGMAR1 (0.82) | KMT2AMEN1SIGMAR1TMEM97MCHR1 | |
| SCHEMBL8274001 | 0.79 | MEN1 (0.78) | KMT2AMEN1SIGMAR1TMEM97MCHR1 | |
| SCHEMBL4240454 | 0.78 | CCR3 (0.59) | MCHR1DRD4CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871770-B2 | Carboxamide compounds and methods for using the same | MIDCAP FINANCIAL TRUST | 2014-10-28 | — | — | US | disclosed |
| US-20140148467-A1 | Carboxamide Compounds and Methods for Using the Same | RIGEL PHARMACEUTICALS, INC. (US) | 2014-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148467-A1 | Carboxamide Compounds and Methods for Using the Same | PC, AK2, PRKAA2 | KMT2A 324/4885MEN1 3205/4885SIGMAR1 2015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.