Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | PTPRB | P23467 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15000428 | 0.95 | KCNH2 (0.43) | SLC6A3DRD2HTR2AHRH1KCNH2 | |
| SCHEMBL10058000 | 0.89 | SLC6A3 (0.45) | SLC6A3DRD2HTR2AHRH1ALDH1A1 | |
| SCHEMBL14638829 | 0.81 | SLC6A3 (0.45) | SLC6A3DRD2HTR2AHRH1ALDH1A1 | |
| SCHEMBL2819185 | 0.80 | SLC6A3 (0.47) | SLC6A3DRD2HTR2AHRH1ESR1 | |
| SCHEMBL15591337 | 0.79 | SLC6A3 (0.44) | SLC6A3DRD2HTR2AHRH1ALDH1A1 | |
| SCHEMBL13045053 | 0.79 | SLC6A3 (0.44) | SLC6A3DRD2HTR2AHRH1NOS2 | |
| SCHEMBL7179624 | 0.79 | SLC6A3 (0.44) | SLC6A3DRD2HTR2AHRH1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15544889 | 0.78 | SLC6A3 (0.43) | SLC6A3DRD2HTR2AHRH1ALDH1A1 | |
| SCHEMBL6222760 | 0.77 | FDPS (0.38) | SLC6A3ESR1ESR2MEN1KMT2A | |
| SCHEMBL6439079 | 0.77 | HRH4 (0.39) | SLC6A3DRD2HTR2AHRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822147-B2 | Methods of treating ophthalmic diseases using NPR-B agonists | SHIRE ORPHAN THERAPIES GMBH (DE) | 2017-11-21 | — | — | US | disclosed |
| WO-2011075471-A2 | NOVEL NPR-B AGONISTS AND METHODS OF USE FOR THE TREATMENT OF C-TYPE NATRIURETIC PEPTIDE-MEDIATED DISORDERS | ALCON RESEARCH, LTD. (US) | 2011-06-23 | — | — | WO | disclosed |