Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 5/20 | 0.46 |
| ▸ | PPID | Q08752 | 3/20 | 0.44 |
| ▸ | PPIG | Q13427 | 3/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2035440 | 0.91 | PPIB (0.49) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL12643831 | 0.86 | PPIB (0.51) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL2037947 | 0.81 | PPIB (0.62) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL19882134 | 0.80 | ALDH1A1 (0.45) | PPIDALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL12643832 | 0.78 | PPIB (0.53) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL2041992 | 0.72 | PPIB (0.51) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL15832171 | 0.71 | PPID (0.56) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL2040991 | 0.70 | PPIB (0.69) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL2036171 | 0.69 | PPIB (0.64) | PPIBPPIDPPIGPPIAALDH1A1 | |
| SCHEMBL2038255 | 0.69 | PPIB (0.58) | PPIBPPIDPPIGPPIAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076784-A2 | NEW INHIBITORS OF CYCLOPHILINS AND USES THEREOF | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2011-06-30 | — | — | WO | disclosed |