Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9807385 | 0.83 | ALDH1A1 (0.53) | CA12CA1CA2CA9MAPT | |
| SCHEMBL8948959 | 0.80 | MAOB (0.70) | MAOBCA12CA1CA2CA7 | |
| SCHEMBL28621039 | 0.80 | CA12 (0.76) | MAOBCA12CA1CA2CA7 | |
| SCHEMBL19387725 | 0.80 | MAOB (0.52) | MAOBCA12CA1CA2CA7 | |
| SCHEMBL22219303 | 0.79 | LMNA (0.59) | MAOBLMNACYP1A2 | |
| SCHEMBL29151254 | 0.79 | MAOB (0.68) | MAOBCA12CA1CA2CA7 | |
| SCHEMBL5597361 | 0.79 | MAOB (0.68) | MAOBCA12CA1CA2CA7 | |
| SCHEMBL13552108 | 0.77 | KMT2A (0.59) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL12644402 | 0.76 | LMNA (0.47) | MAOBCA12CA1CA2CA7 | |
| SCHEMBL10651178 | 0.76 | MAOB (0.68) | MAOBCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075210-A2 | SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | WO | disclosed |