Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12644451 | 0.86 | MAOB (0.45) | LMNAMAOBKCNH2MAPTMAPK1 | |
| SCHEMBL13551971 | 0.81 | GAA (0.45) | MAOBKCNH2MAPTMEN1KMT2A | |
| SCHEMBL13551992 | 0.78 | MAPT (0.44) | MAOBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL19387677 | 0.77 | HTR2A (0.37) | LMNAMAOBKCNH2MAPTMAPK1 | |
| SCHEMBL1818150 | 0.77 | LMNA (0.60) | LMNAMAOBMAPTMEN1KMT2A | |
| SCHEMBL12644251 | 0.76 | MAOB (0.59) | LMNAMAOBMAPTMAPK1MEN1 | |
| SCHEMBL12644466 | 0.74 | MAPT (0.44) | MAOBMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12644214 | 0.74 | KMT2A (0.55) | MAOBKCNH2MAPTMAPK1MEN1 | |
| SCHEMBL12643999 | 0.72 | MAPT (0.42) | MAOBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL19387723 | 0.72 | MAOB (0.35) | LMNAMAOBKCNH2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075210-A2 | SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | WO | disclosed |