Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19387677 | 0.85 | HTR2A (0.37) | MAOBMAPTPOLBHTR2AMEN1 | |
| SCHEMBL12644466 | 0.81 | MAPT (0.44) | MAOBMAPTPOLBMEN1KMT2A | |
| SCHEMBL12644388 | 0.76 | MAPT (0.39) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL12644453 | 0.74 | BRD4 (0.41) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL12644451 | 0.73 | MAOB (0.45) | MAOBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL12644402 | 0.72 | LMNA (0.47) | MAOBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13551992 | 0.72 | MAPT (0.44) | MAOBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL19387713 | 0.72 | MAPT (0.37) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12644392 | 0.71 | BRD4 (0.41) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL12643999 | 0.71 | MAPT (0.42) | MAOBMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771321-B2 | Small molecules that covalently modify transthyretin | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-09-26 | — | — | US | disclosed |