SCHEMBL1264757

SCHEMBL1264757

C=CCc1cccc(-n2nc3ccccc3n2)c1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.51
GABRB2 P47870 1/20 0.51
MEN1 O00255 9/20 0.47
KMT2A Q03164 9/20 0.47
PKM P14618 4/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
MAPT P10636 6/20 0.44
ALDH1A1 P00352 4/20 0.44
LMNA P02545 4/20 0.44
NPSR1 Q6W5P4 3/20 0.44
HTT P42858 3/20 0.44
USP2 O75604 2/20 0.44
HIF1A Q16665 1/20 0.44
TP53 P04637 1/20 0.44
ALOX15 P16050 2/20 0.43
POLB P06746 1/20 0.43
ATM Q13315 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MAPK1 P28482 1/20 0.43
AKR1B1 P15121 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9175550 0.82 NPC1 (0.44) GABRA1GABRB2MEN1KMT2AMAPT
SCHEMBL712510 0.81 NPC1 (0.43) GABRA1GABRB2MEN1KMT2APKM
SCHEMBL2223774 0.81 NPC1 (0.43) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL285279 0.80 NPC1 (0.58) GABRA1GABRB2MEN1KMT2APKM
SCHEMBL28236651 0.80 POLB (0.49) GABRA1GABRB2MEN1KMT2APKM
SCHEMBL29384819 0.80 NPC1 (0.58) GABRA1GABRB2MEN1KMT2APKM
SCHEMBL9408926 0.80 NPC1 (0.42) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL13121650 0.80 GABRA1 (0.52) GABRA1GABRB2ALDH1A1LMNAPOLB
SCHEMBL2221992 0.80 NPC1 (0.45) GABRA1GABRB2MEN1KMT2AMAPT
SCHEMBL28234016 0.78 NPC1 (0.40) GABRA1GABRB2MEN1KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4286682-A None JP disclosed
EP-3320055-B1 SUBSTITUTED BENZOTRIAZOLE PHENOLATE SALTS AND ANTIOXIDANT COMPOSITIONS FORMED THEREFROM 3M INNOVATIVE PROPERTIES CO (US) 2021-03-03 EP disclosed
EP-3320135-B1 ELECTRET WEBS WITH CHARGE-ENHANCING ADDITIVES 3M INNOVATIVE PROPERTIES CO (US) 2019-08-28 EP disclosed
US-8163934-B2 Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole CHANG CHIA-HU (US) 2012-04-24 US disclosed
EP-2332013-A1 ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE Chang, Chia-Hu (US) 2011-06-15 EP disclosed
US-20110038816-A1 Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole CHANG CHIA-HU 2011-02-17 US disclosed
US-7847103-B2 Ultraviolet light absorbing ketones of 2-(2-hydroxyphenyl) benzotriazole CHANG CHIA-HU 2010-12-07 US disclosed
US-20100086500-A1 Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole CHANG CHIA-HU 2010-04-08 US disclosed
WO-2010039229-A1 ULTRAVIOLET LIGHT ABSORBING KETONES OF 2-(2-HYDROXYPHENYL) BENZOTRIAZOLE CHANG CHIA-HU (US) 2010-04-08 WO disclosed
EP-1428520-A2 Lipase inhibitors in deodorants and antiperspirants Henkel Kommanditgesellschaft auf Aktien (DE) 2004-06-16 EP disclosed
JP-H04286682-A DEVELOPING SHEET FOR PRESSURE SENSITIVE RECORDING FUJI PHOTO FILM CO LTD 1992-10-12 JP disclosed
US-4214016-A ACRYLIC ESTER COPOLYMER, POLYISOCYANATE, ULTRAVIOLET ABSORBER, UNSATURATED POLYESTER TOYODA GOSEI KABUSHIKI-KAISHA (TOYODA SYNTHETICS CO., LTD.) (JP) 1980-07-22 US disclosed
US-4129521-A Branched chain nonyl and dodecyl isomeric mixtures of 2-(5'-nonyl, or dodecyl-2'-hydroxyphenyl)benzotriazole as UV stabilizers GAF CORPORATION (US) 1978-12-12 US disclosed
US-4096242-A ULTRAVIOLET AND HEAT RESISTANCE GAF CORPORATION (US) 1978-06-20 US disclosed
US-RE29596-E Branched chain dodecyl isomeric mixtures of 2-(5-dodecyl-2-hydroxy phenyl) benzotriazole as stabilizers for heat and light sensitive materials GAF CORPORATION (US) 1978-03-28 US disclosed
US-3983132-A Branched chain dodecyl isomeric mixtures of 2-(5-dodecyl-2-hydroxy phenyl) benzotriazole as stabilizers for heat and light sensitive materials GAF CORPORATION (US) 1976-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110038816-A1 Ultraviolet light absorbing ketones of 2-(2-hydroxyhenyl) benzotriazole HCRTR2, HCRTR1, POLL GABRA1 91/4885GABRB2 76/4885MEN1 4223/4885
US-20100086500-A1 Ultraviolet light absorbing ketones of 2-(2-Hydroxyphenyl) benzotriazole HCRTR2, HCRTR1, PAH GABRA1 92/4885GABRB2 87/4885MEN1 4309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.