Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19036251 | 0.93 | SMN1; SMN2 (0.40) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL19036161 | 0.89 | HRH1 (0.41) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL12181288 | 0.89 | CHRM1 (0.33) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL14286145 | 0.87 | HRH3 (0.33) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL13510860 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL15138014 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL13510862 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL420320 | 0.82 | CHRM1 (0.46) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL18717218 | 0.82 | HRH3 (0.36) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A | |
| SCHEMBL13160756 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2CHRM1CHRM2CHRM4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943179-B2 | Drug delivery particle; useful in genetic vaccination; eg poly(beta-amino esters) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-05-17 | — | — | US | disclosed |