Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 4/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604336 | 0.88 | CNR2 (0.41) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604357 | 0.88 | CNR2 (0.41) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604354 | 0.86 | PDE1A (0.44) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604341 | 0.81 | CNR2 (0.42) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604409 | 0.79 | CACNA1H (0.37) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604342 | 0.75 | PDE1A (0.42) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604333 | 0.74 | PDE1A (0.48) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604347 | 0.72 | NR3C1 (0.39) | ALDH1A1HPGDNPSR1HSD17B10GAA | |
| SCHEMBL12604334 | 0.71 | UCHL1 (0.51) | PDE1APDE1BPDE1CALDH1A1LMNA | |
| SCHEMBL12604349 | 0.71 | UCHL1 (0.51) | PDE1APDE1BPDE1CALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118249-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BOEHRINGER INGLEHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118249-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | RTF2, CCNY, RTF1 | PDE1A 4666/4885PDE1B 4698/4885PDE1C 4773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.