Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | ATG7 | O95352 | 2/20 | 0.53 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.53 |
| ▸ | UBA7 | P41226 | 1/20 | 0.53 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.53 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.53 |
| ▸ | DNPH1 | O43598 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12566849 | 0.90 | UBA6 (0.58) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL12566847 | 0.88 | DNPH1 (0.62) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL12567223 | 0.86 | CA1 (0.56) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL1797321 | 0.84 | NAE1 (0.53) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL12566836 | 0.83 | ATG7 (0.56) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL12652509 | 0.83 | ATG7 (0.56) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL1796907 | 0.83 | DNPH1 (0.73) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL1795883 | 0.81 | ATG7 (0.57) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL11889887 | 0.81 | ATG7 (0.57) | CA1CA2CA4CA9ATG7 | |
| SCHEMBL12566425 | 0.81 | DNPH1 (0.62) | CA1CA2CA4CA9ATG7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951810-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |