Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 9/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12959030 | 0.90 | FGFR4 (0.45) | FGFR4RAF1GPR52FAAHKIF18A | |
| SCHEMBL12805950 | 0.90 | FGFR4 (0.45) | FGFR4RAF1GPR52FAAHKIF18A | |
| SCHEMBL12805953 | 0.90 | FGFR4 (0.45) | FGFR4RAF1GPR52FAAHKIF18A | |
| SCHEMBL17655353 | 0.88 | RAF1 (0.39) | FGFR4RAF1GPR52BRAFCA2 | |
| SCHEMBL17655444 | 0.86 | FGFR4 (0.42) | FGFR4RAF1GPR52BRAFKIF18A | |
| SCHEMBL12653828 | 0.83 | FGFR4 (0.45) | FGFR4RAF1GPR52BRAFPRMT5 | |
| SCHEMBL18415686 | 0.83 | FGFR4 (0.44) | FGFR4GPR52PRMT5WDR77 | |
| SCHEMBL17655393 | 0.82 | GPR52 (0.37) | FGFR4RAF1GPR52FAAHKIF18A | |
| SCHEMBL18415693 | 0.82 | RAF1 (0.37) | RAF1GPR52PRMT5WDR77CA2 | |
| SCHEMBL19365868 | 0.81 | GPR52 (0.38) | FGFR4RAF1GPR52KIF18APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |