Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655348 | 0.89 | RAF1 (0.37) | RAF1 | |
| SCHEMBL12805950 | 0.88 | FGFR4 (0.45) | RAF1FGFR4GPR52CNR2CA2 | |
| SCHEMBL12805953 | 0.88 | FGFR4 (0.45) | RAF1FGFR4GPR52CNR2CA2 | |
| SCHEMBL12959030 | 0.88 | FGFR4 (0.45) | RAF1FGFR4GPR52CNR2CA2 | |
| SCHEMBL12653773 | 0.88 | FGFR4 (0.38) | RAF1BRAFFGFR4EGFRGPR52 | |
| SCHEMBL17655444 | 0.83 | FGFR4 (0.42) | RAF1BRAFFGFR4GPR52 | |
| SCHEMBL18415693 | 0.81 | RAF1 (0.37) | RAF1GPR52CA2CA9TRPV3 | |
| SCHEMBL18415686 | 0.81 | FGFR4 (0.44) | FGFR4GPR52 | |
| SCHEMBL19365868 | 0.81 | GPR52 (0.38) | RAF1FGFR4GPR52CA2CA9 | |
| SCHEMBL17655442 | 0.81 | GPR52 (0.36) | RAF1FGFR4GPR52CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |