Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 9/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650416 | 0.89 | DOCK5 (0.47) | DOCK5METAP2 | |
| SCHEMBL1650417 | 0.89 | DOCK5 (0.47) | DOCK5METAP2 | |
| SCHEMBL15484518 | 0.89 | DOCK5 (0.47) | DOCK5METAP2 | |
| SCHEMBL1650721 | 0.89 | DOCK5 (0.47) | DOCK5METAP2 | |
| SCHEMBL1650705 | 0.88 | DOCK5 (0.48) | DOCK5LIPEHRH3METAP2 | |
| SCHEMBL12076016 | 0.88 | HSD11B1 (0.42) | USP30METAP2 | |
| SCHEMBL1650708 | 0.88 | DOCK5 (0.48) | DOCK5LIPEHRH3METAP2 | |
| SCHEMBL15416974 | 0.88 | DOCK5 (0.48) | DOCK5LIPEHRH3METAP2 | |
| SCHEMBL15416973 | 0.87 | METAP2 (0.43) | LIPEHRH3METAP2 | |
| SCHEMBL12076092 | 0.87 | BACE1 (0.43) | LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011053575-A1 | SPIROLACTAM DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-05-05 | — | — | WO | disclosed |