Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655388 | 0.89 | FGFR4 (0.47) | FGFR4GPR142PIK3CADYRK1AFAAH | |
| SCHEMBL12654407 | 0.86 | GPR142 (0.47) | FGFR4GPR142PIK3CADYRK1ACYP11B2 | |
| SCHEMBL17655331 | 0.85 | GPR142 (0.44) | FGFR4GPR142DYRK1ACYP11B2ABL1 | |
| SCHEMBL12654181 | 0.85 | MPL (0.42) | FGFR4GPR142FAAHGRM5 | |
| SCHEMBL12959048 | 0.85 | FGFR4 (0.40) | FGFR4GPR142FAAH | |
| SCHEMBL12654406 | 0.84 | GPR142 (0.42) | FGFR4GPR142DYRK1ACYP11B2ABL1 | |
| SCHEMBL12958969 | 0.84 | FGFR4 (0.49) | FGFR4GPR142DYRK1AFAAHCYP11B2 | |
| SCHEMBL12654183 | 0.84 | FGFR4 (0.39) | FGFR4GPR142FAAHABL1RPS6KA2 | |
| SCHEMBL17655437 | 0.83 | NPC1 (0.41) | FGFR4GPR142DYRK1AWNT3A | |
| SCHEMBL19365327 | 0.83 | FAAH (0.36) | FGFR4FAAHCYP11B2ABL1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |