Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 11/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655343 | 0.89 | FGFR4 (0.46) | GRM5FGFR4CNR2 | |
| SCHEMBL12653785 | 0.87 | FGFR4 (0.59) | FGFR4CNR2CNR1 | |
| SCHEMBL12654660 | 0.86 | FGFR4 (0.46) | FGFR4RAB9A | |
| SCHEMBL12654216 | 0.84 | FGFR4 (0.62) | FGFR4CNR2 | |
| SCHEMBL12654413 | 0.84 | GRM5 (0.45) | GRM5RAB9ACNR2FPR2CNR1 | |
| SCHEMBL17655398 | 0.84 | FGFR4 (0.47) | GRM5FGFR4CNR2CNR1 | |
| SCHEMBL1812175 | 0.83 | CNR1 (0.43) | FGFR4CNR2CNR1 | |
| SCHEMBL12654207 | 0.83 | FGFR4 (0.52) | FGFR4 | |
| SCHEMBL17655390 | 0.82 | GRM5 (0.47) | GRM5RAB9ACNR2CNR1 | |
| SCHEMBL12653816 | 0.82 | GCK (0.48) | GRM5FGFR4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |