Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654669 | 0.88 | CNR2 (0.50) | FGFR4ALDH1A1CNR2SIRT2KMT2A | |
| SCHEMBL12654526 | 0.86 | MPL (0.42) | CNR2GRM5 | |
| SCHEMBL12654659 | 0.86 | FGFR4 (0.41) | FGFR4EPHX2ALDH1A1CNR2IDO1 | |
| SCHEMBL17655390 | 0.85 | GRM5 (0.47) | ALDH1A1CNR2MAPTKMT2AGRM5 | |
| SCHEMBL19365232 | 0.84 | FGFR4 (0.47) | FGFR4EPHX2GRM5 | |
| SCHEMBL12654429 | 0.84 | PHGDH (0.41) | ALDH1A1CNR2MEN1KMT2AGRM5 | |
| SCHEMBL17655361 | 0.83 | ROCK2 (0.36) | CNR2MAPT | |
| SCHEMBL12654670 | 0.82 | CNR1 (0.38) | ALDH1A1CNR2MEN1MAPTKMT2A | |
| SCHEMBL17655384 | 0.82 | TP53 (0.40) | CNR2SIRT2MEN1MAPTKMT2A | |
| SCHEMBL12654207 | 0.82 | FGFR4 (0.52) | FGFR4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |