Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655393 | 0.85 | GPR52 (0.37) | TRPV3KIF18ANPY5RFGFR4TRPV1 | |
| SCHEMBL18415692 | 0.83 | GRM5 (0.36) | GRM5CNR2TRPV3KIF18ACNR1 | |
| SCHEMBL12654413 | 0.83 | GRM5 (0.45) | GRM5CNR2CNR1 | |
| SCHEMBL12653784 | 0.83 | CNR2 (0.51) | GRM5CNR2NPY5RFGFR4CNR1 | |
| SCHEMBL12654219 | 0.81 | FGFR4 (0.43) | GRM5CNR2NPY5RFGFR4CNR1 | |
| SCHEMBL18415687 | 0.80 | FGFR4 (0.42) | FGFR4 | |
| SCHEMBL1812181 | 0.80 | MPL (0.41) | GRM5CNR2FGFR4CNR1 | |
| SCHEMBL17655422 | 0.80 | KIF18A (0.36) | TRPV3KIF18ANPY5RFGFR4TRPV1 | |
| SCHEMBL17655442 | 0.80 | GPR52 (0.36) | TRPV3KIF18ANPY5RFGFR4TRPV1 | |
| SCHEMBL12654415 | 0.79 | GRM5 (0.34) | GRM5CNR2TRPV3KIF18ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |