Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12622493 | 0.95 | CKS1B (0.43) | SUV39H2BRD4HTR2BHTR6HDAC3 | |
| SCHEMBL12622482 | 0.87 | SUV39H2 (0.44) | SUV39H2BRD4PDE10ABTKHDAC3 | |
| SCHEMBL1814237 | 0.87 | SUV39H2 (0.41) | SUV39H2BRD4PDE10APIM1PIM3 | |
| SCHEMBL1813569 | 0.83 | BRD4 (0.44) | SUV39H2BRD4BTKHDAC3HDAC1 | |
| SCHEMBL1811364 | 0.82 | SIRT6 (0.41) | SUV39H2BRD4CKS1BSKP1SKP2 | |
| SCHEMBL1814238 | 0.82 | BRD4 (0.43) | SUV39H2BRD4PDE10APIM1PIM3 | |
| SCHEMBL12622502 | 0.77 | HTR6 (0.47) | SUV39H2PDE10ABTKHTR2BHTR6 | |
| SCHEMBL12622483 | 0.76 | SUV39H2 (0.42) | SUV39H2PDE10APIM1PIM3PIM2 | |
| SCHEMBL7242505 | 0.76 | SUV39H2 (0.50) | SUV39H2BTKHDAC3HDAC1HDAC2 | |
| SCHEMBL15092141 | 0.76 | SUV39H2 (0.48) | SUV39H2PDE10ABTKHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939520-B2 | Aminoazacyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands | WYETH LLC (US) | 2011-05-10 | — | — | US | disclosed |
| WO-2008144299-A1 | 5- (AMINOAZACYCLYL) -3-SULFONYL-LH- INDAZOLES AS 5-HYDROXYTRYPTAMINE- 6 LIGANDS FOR THE TREATMENT OF CNS DISORDERS | WYETH (US) | 2008-11-27 | — | — | WO | disclosed |
| US-20080293688-A1 | AMINOAZACYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293688-A1 | AMINOAZACYCLYL-3-SULFONYLINDAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | HTR6, HTR3B, HTR5A | SUV39H2 2916/4885BRD4 1543/4885PDE10A 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.