Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12656438 | 1.00 | KMT2A (0.46) | KMT2AHPGDMEN1CARM1PRMT6 | |
| SCHEMBL16244235 | 0.88 | KMT2A (0.57) | KMT2AHPGDMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27560928 | 0.84 | HPGD (0.47) | KMT2AHPGDMEN1CARM1PRMT6 | |
| SCHEMBL1019372 | 0.84 | KMT2A (0.59) | KMT2AHPGDMEN1CARM1PRMT6 | |
| SCHEMBL1576594 | 0.84 | KMT2A (0.59) | KMT2AHPGDMEN1CARM1PRMT6 | |
| SCHEMBL15331025 | 0.83 | ALDH1A1 (0.46) | KMT2AHPGDMEN1CARM1PRMT6 | |
| SCHEMBL400373 | 0.82 | CXCL8 (0.42) | KMT2AHPGDMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10013408 | 0.82 | CXCL8 (0.42) | KMT2AHPGDMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10013407 | 0.82 | CXCL8 (0.42) | KMT2AHPGDMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28822687 | 0.81 | F9 (0.47) | KMT2AHPGDMEN1CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316829-A1 | Heterocyclic derivatives as modulators of ion channels | Vertex Pharmaceuticals Incorporated (US) | 2011-05-04 | — | — | EP | disclosed |
| EP-2308872-A1 | Heterocyclic derivatives as modulators of ion channels | Vertex Pharmaceuticals Incorporated (US) | 2011-04-13 | — | — | EP | disclosed |