Sugi Predict

Sugi Predict / Compounds / SCHEMBL12658141

SCHEMBL12658141

SCHEMBL12658141

COc1cc(Cl)cc(C)c1C1=C(O)C(C)NC1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSNK2A2 P19784 5/20 0.38
▸ CSNK2B P67870 5/20 0.38
▸ CSNK2A1 P68400 5/20 0.38
▸ MAP3K14 Q99558 1/20 0.37
▸ ERN1 O75460 1/20 0.36
▸ GSK3B P49841 4/20 0.34
▸ CDK4 P11802 1/20 0.34
▸ CCNA2 P20248 1/20 0.34
▸ CCND1 P24385 1/20 0.34
▸ CDK2 P24941 1/20 0.34
▸ CCNA1 P78396 1/20 0.34
▸ STK10 O94804 3/20 0.34
▸ SLK Q9H2G2 3/20 0.34
▸ GSK3A P49840 2/20 0.34
▸ CYP19A1 P11511 1/20 0.33
▸ NQO2 P16083 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.32
▸ POLB P06746 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ CES1 P23141 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12269978 0.83 STK10 (0.36) CSNK2A2CSNK2BCSNK2A1ERN1GSK3B
SCHEMBL12703009 0.78 ALDH1A1 (0.32) MAP3K14ALDH1A1POLBHSD17B10
SCHEMBL13673438 0.78 STK10 (0.38) CSNK2A2CSNK2BCSNK2A1ERN1GSK3B
SCHEMBL12658146 0.77 MAP3K14 (0.36) MAP3K14ALDH1A1POLB
SCHEMBL12658142 0.73 ACACB (0.39) CSNK2A2CSNK2BCSNK2A1MAP3K14ERN1
SCHEMBL12858917 0.71 ACACB (0.49) MAP3K14ALDH1A1HSD17B10
SCHEMBL14432179 0.69 GRIN2D (0.34) ALDH1A1GAA
SCHEMBL12658327 0.69 ERN1 (0.37) CSNK2A2CSNK2BCSNK2A1MAP3K14ERN1
SCHEMBL12658145 0.69 ACACB (0.47) ALDH1A1
SCHEMBL12022351 0.68 ACACB (0.57) MAP3K14GSK3BCDK4CCNA2CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1606254-B1 2,4,6-PHENYL SUBSTITUTED CYCLIC KETOENOLS BAYER CROPSCIENCE AG (DE) 2011-05-11 — — EP disclosed
US-20110092368-A1 2,4,6-Phenyl-substituted cyclic ketoenols FISCHER REINER 2011-04-21 — — US disclosed
US-20110092368-A1 2,4,6-Phenyl-substituted cyclic ketoenols FISCHER REINER 2011-04-21 — — US disclosed
US-7888285-B2 2,4,6-phenyl substituted cyclic ketoenols BAYER CROPSCIENCE AG (DE) 2011-02-15 — — US disclosed
US-7888285-B2 2,4,6-phenyl substituted cyclic ketoenols BAYER CROPSCIENCE AG (DE) 2011-02-15 — — US disclosed
US-20070015664-A1 2,4,6-Phenyl substituted cyclic ketoenols BAYER CROPSCIENCE AG (DE) 2007-01-18 — — US disclosed
US-20070015664-A1 2,4,6-Phenyl substituted cyclic ketoenols BAYER CROPSCIENCE AG (DE) 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015664-A1 2,4,6-Phenyl substituted cyclic ketoenols CYP4X1, KDM4E, KCNE1 CSNK2A2 244/4885CSNK2B 353/4885CSNK2A1 263/4885
US-20110092368-A1 2,4,6-Phenyl-substituted cyclic ketoenols CYP4X1, KDM4E, PDHX CSNK2A2 304/4885CSNK2B 446/4885CSNK2A1 333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.