Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.58 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.58 |
| ▸ | HEXA | P06865 | 3/20 | 0.55 |
| ▸ | HEXB | P07686 | 3/20 | 0.55 |
| ▸ | OGA | O60502 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12660542 | 0.94 | SIRT1 (0.66) | KEAP1NFE2L2TLR9SIRT1USP2 | |
| SCHEMBL12660534 | 0.91 | KEAP1 (0.60) | KEAP1NFE2L2TLR9SIRT1USP2 | |
| SCHEMBL13964867 | 0.87 | KMT2A (0.67) | KEAP1NFE2L2TLR9USP2KMT2A | |
| SCHEMBL29086656 | 0.85 | HEXA (0.67) | KEAP1NFE2L2TLR9USP2KMT2A | |
| SCHEMBL12660568 | 0.84 | SIRT1 (0.54) | KEAP1NFE2L2TLR9SIRT1USP2 | |
| SCHEMBL13964866 | 0.84 | USP2 (0.70) | KEAP1NFE2L2TLR9USP2KMT2A | |
| SCHEMBL3290712 | 0.82 | SIRT1 (0.86) | SIRT1HEXAHEXBOGA | |
| SCHEMBL3292141 | 0.82 | SIRT1 (0.81) | SIRT1HEXAHEXBOGA | |
| SCHEMBL9093307 | 0.81 | SIRT1 (0.60) | TLR9SIRT1USP2KMT2AMEN1 | |
| SCHEMBL9091826 | 0.81 | KDM4E (0.59) | TLR9SIRT1USP2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-7947839-B2 | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use | GENENTECH, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| WO-2007064345-A9 | HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE | GENENTECH INC (US) | 2007-07-12 | — | — | WO | disclosed |
| US-20070134243-A1 | Antibody drug conjugates and methods | GENENTECH, INC. | 2007-06-14 | — | — | US | disclosed |
| US-20070134243-A1 | Antibody drug conjugates and methods | GENENTECH, INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070134243-A1 | Antibody drug conjugates and methods | BOD1L1, MKI67, CCNI | KEAP1 1373/4885NFE2L2 2213/4885TLR9 2646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.