Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194744 | 0.83 | TDP1 (0.54) | TDP1TSHRMAPK1MAOBMAPT | |
| SCHEMBL10938457 | 0.79 | TDP1 (0.50) | TDP1TSHRMAPK1MAOBMAPT | |
| SCHEMBL23532379 | 0.79 | CA12 (0.52) | TSHRMAPK1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL11316263 | 0.78 | TDP1 (0.48) | TDP1TSHRMAPK1MAOBMAPT | |
| SCHEMBL11311338 | 0.78 | TDP1 (0.48) | TDP1TSHRMAPK1MAOBMAPT | |
| SCHEMBL8443089 | 0.77 | LTA4H (0.52) | APPKMT2AMEN1LTA4HPTGS1 | |
| SCHEMBL14090012 | 0.77 | NQO1 (0.39) | TDP1TSHRMAPTGAASMN1; SMN2 | |
| SCHEMBL4704964 | 0.76 | KCNA3 (0.50) | TDP1ALDH1A1LTA4H | |
| SCHEMBL11314136 | 0.75 | TDP1 (0.46) | TDP1TSHRMAPK1MAOBMAPT | |
| SCHEMBL18883707 | 0.74 | MAOB (0.44) | MAOBMAPTGAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939666-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-05-10 | — | — | US | disclosed |
| US-20090291978-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291978-A1 | Enzyme Inhibitors | HAT1, NR2E1, NR2C2 | TDP1 3073/4885TSHR 1357/4885MAPK1 2308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.