Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349615 | 0.86 | KDM4E (0.52) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL16256947 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL8082196 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL13168260 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL28769835 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL27897800 | 0.82 | DRD4 (0.55) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL27707250 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL27728208 | 0.82 | DRD4 (0.55) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL27605771 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2HPGDKMT2ADRD4GRM2 | |
| SCHEMBL23207522 | 0.80 | KDM4E (0.62) | SMN1; SMN2HPGDKMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105493-A1 | HETEROCYCLYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105493-A1 | HETEROCYCLYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS | ADORA2A, ADORA3, ADORA2B | SMN1; SMN2 999/4885HPGD 1163/4885KMT2A 1541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.