Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13168167 | 0.83 | CYP2C9 (0.39) | SMN1; SMN2HPGDKMT2ACXCR3MEN1 | |
| SCHEMBL14996519 | 0.83 | MAPT (0.49) | SMN1; SMN2HPGDKMT2AMAPTKDM4E | |
| SCHEMBL12668912 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2HPGDKMT2AMAPTKDM4E | |
| SCHEMBL13131034 | 0.81 | MAPT (0.48) | SMN1; SMN2HPGDKMT2AMAPTKDM4E | |
| SCHEMBL11955829 | 0.80 | CA12 (0.43) | SMN1; SMN2MAPTKDM4EGAADRD4 | |
| SCHEMBL485221 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDKMT2AMAPTKDM4E | |
| SCHEMBL13168259 | 0.77 | HRH3 (0.40) | KDM4EGRM2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL648751 | 0.76 | KDM4E (0.54) | SMN1; SMN2HPGDKMT2AMAPTKDM4E | |
| SCHEMBL13168160 | 0.75 | HSD17B10 (0.57) | SMN1; SMN2HPGDKMT2AMAPTKDM4E | |
| SCHEMBL485461 | 0.74 | KCNH2 (0.48) | SMN1; SMN2HPGDKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | SMN1; SMN2 3545/4885HPGD 386/4885KMT2A 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.