Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | WRN | Q14191 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.35 |
| ▸ | PGR | P06401 | 4/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873300 | 0.83 | S1PR1 (0.48) | S1PR1BLMWRNPTGDR2CNR2 | |
| SCHEMBL19507960 | 0.82 | S1PR1 (0.53) | S1PR1BLMWRNPTGDR2CNR2 | |
| SCHEMBL1875379 | 0.82 | KDM4E (0.53) | S1PR1BLMWRN | |
| SCHEMBL1874904 | 0.72 | SNCA (0.51) | S1PR1BLMWRNPTGDR2CNR2 | |
| SCHEMBL1514661 | 0.71 | VCP (0.44) | S1PR1BLMWRNPTGDR2CNR2 | |
| SCHEMBL9965314 | 0.69 | HSD17B1 (0.45) | S1PR1CNR2FLT3CYP11B1CYP11B2 | |
| SCHEMBL2407001 | 0.69 | LRRK2 (0.53) | S1PR1FLT3CYP11B1CYP11B2PGR | |
| SCHEMBL13857736 | 0.69 | TRPV3 (0.38) | S1PR1BLMWRNPTGDR2CNR2 | |
| SCHEMBL1514274 | 0.68 | CYP11B1 (0.57) | PTGDR2CNR2FLT3CYP11B1CYP11B2 | |
| SCHEMBL2924723 | 0.67 | PIK3CD (0.50) | BLMWRNFLT3CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060391-A1 | SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS | RECEPTOS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |