Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.82 |
| ▸ | PKM | P14618 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CFTR | P13569 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.47 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22386371 | 0.74 | MEN1 (0.65) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL17309380 | 0.74 | MEN1 (0.65) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL3364192 | 0.72 | CFTR (1.00) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL3364187 | 0.72 | CFTR (1.00) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL10668045 | 0.71 | ALDH1A1 (0.52) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL10668039 | 0.71 | ALDH1A1 (0.52) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL2176166 | 0.70 | HSD17B3 (0.61) | MEN1KMT2AALDH1A1 | |
| SCHEMBL2176164 | 0.70 | HSD17B3 (0.61) | MEN1KMT2AALDH1A1 | |
| SCHEMBL17779727 | 0.69 | PTPN12 (0.62) | KMT2A | |
| SCHEMBL2172737 | 0.68 | AURKA (0.48) | MEN1KMT2APKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105565-A1 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105565-A1 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, PKD1, PKD2 | MEN1 2136/4885KMT2A 4437/4885PKM 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.