Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364187 | 1.00 | CFTR (1.00) | CFTRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL7852521 | 0.83 | MAPK1 (0.76) | CFTRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL16130239 | 0.81 | CFTR (0.68) | CFTRS1PR4S1PR1S1PR5 | |
| SCHEMBL12912717 | 0.80 | CFTR (0.66) | CFTRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL15828869 | 0.79 | KMT2A (0.79) | CFTRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL27618822 | 0.77 | MEN1 (0.67) | CFTRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL16130330 | 0.76 | S1PR1 (0.65) | CFTRKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL16130327 | 0.75 | S1PR1 (0.66) | CFTRCA9DYRK2PIM1CDK5 | |
| SCHEMBL16130333 | 0.75 | S1PR1 (0.61) | CFTRS1PR4S1PR1S1PR5 | |
| SCHEMBL17309314 | 0.75 | ALDH1A1 (0.61) | CFTRKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689726-B1 | 5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-10-06 | — | — | EP | disclosed |