Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.54 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ERN1 | O75460 | 3/20 | 0.48 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.47 |
| ▸ | ITGAL | P20701 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12674875 | 0.89 | ERN1 (0.61) | RAB9ANPC1TDP1ALDH1A1HPGD | |
| SCHEMBL12675816 | 0.78 | ALDH1A1 (0.44) | RAB9ATDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL12675425 | 0.77 | ERN1 (0.58) | ALDH1A1HPGDKDM4ETRPV1L3MBTL1 | |
| SCHEMBL30163508 | 0.76 | RAB9A (0.57) | RAB9ANPC1TDP1ALDH1A1HPGD | |
| SCHEMBL31428532 | 0.75 | RAB9A (0.56) | RAB9ANPC1TDP1ALDH1A1HPGD | |
| SCHEMBL12675814 | 0.75 | ERN1 (0.41) | ALDH1A1ERN1 | |
| SCHEMBL12674912 | 0.75 | FKBP1A (0.50) | RAB9ANPC1ALDH1A1HPGDKDM4E | |
| SCHEMBL12675818 | 0.74 | IAPP (0.55) | RAB9ATDP1ALDH1A1HPGDKDM4E | |
| SCHEMBL13681543 | 0.73 | RAB9A (0.61) | RAB9ANPC1TDP1ALDH1A1HPGD | |
| SCHEMBL12675653 | 0.72 | ERN1 (0.60) | RAB9ANPC1ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056744-A1 | IRE-1 α INHIBITORS | MANNKIND CORPORATION (US) | 2011-05-12 | — | — | WO | disclosed |