Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 6/20 | 0.42 |
| ▸ | SKP1 | P63208 | 6/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 6/20 | 0.42 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639525 | 0.82 | CKS1B (0.42) | CKS1BSKP1SKP2DHFRSLC9A1 | |
| SCHEMBL22694441 | 0.80 | ALDH1A1 (0.46) | CKS1BSKP1SKP2SLC9A1NPSR1 | |
| SCHEMBL22722665 | 0.78 | CKS1B (0.39) | CKS1BSKP1SKP2DHFRSLC9A1 | |
| SCHEMBL12670578 | 0.78 | CNR2 (0.40) | CKS1BSKP1SKP2DHFRSLC9A1 | |
| SCHEMBL22694387 | 0.76 | ALDH1A1 (0.40) | CKS1BSKP1SKP2NPSR1HTT | |
| SCHEMBL22694425 | 0.76 | PDE10A (0.39) | CKS1BSKP1SKP2MEN1KMT2A | |
| SCHEMBL12127379 | 0.75 | DHFR (0.39) | DHFRSLC9A1MAPTKDM4EALDH1A1 | |
| SCHEMBL12309910 | 0.69 | HPGD (0.45) | SLC9A1HTTMAPTMEN1KMT2A | |
| SCHEMBL1330773 | 0.68 | SLC9A1 (0.39) | DHFRSLC9A1MAPTMEN1KMT2A | |
| SCHEMBL25592404 | 0.67 | PTGS1 (0.50) | DHFRHTTMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210078990-A1 | TYROSINE KINASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-18 | — | — | US | disclosed |
| US-20130018051-A1 | BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20110105512-A1 | BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105512-A1 | BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | ERBB2, AXL, ERBB3 | CKS1B 152/4885SKP1 1692/4885SKP2 482/4885 |
| US-20210078990-A1 | TYROSINE KINASE INHIBITORS | TYRO3, RET, AXL | CKS1B 424/4885SKP1 632/4885SKP2 1059/4885 |
| US-20130018051-A1 | BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, ERBB2, TYRO3 | CKS1B 220/4885SKP1 1915/4885SKP2 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.