SCHEMBL12680433

SCHEMBL12680433

COc1ccc(N(c2ccc(C)cc2)c2ccc(C=Cc3ccccc3)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RELA Q04206 9/20 0.68
TRPA1 O75762 1/20 0.68
TRPM8 Q7Z2W7 1/20 0.49
ACHE P22303 1/20 0.48
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
NFE2L2 Q16236 3/20 0.47
APP P05067 1/20 0.47
TUBB1 Q9H4B7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10704229 0.97 RELA (0.68) RELATRPA1TRPM8ACHEMAOA
SCHEMBL4407615 0.97 RELA (0.68) RELATRPA1TRPM8ACHEMAOA
SCHEMBL16489743 0.97 RELA (0.68) RELATRPA1TRPM8ACHEMAOA
SCHEMBL5487752 0.93 TRPA1 (0.78) RELATRPA1TRPM8NFE2L2APP
SCHEMBL5487747 0.93 TRPA1 (0.78) RELATRPA1TRPM8NFE2L2APP
SCHEMBL12576222 0.93 RELA (0.78) RELATRPA1ACHEMAOAMAOB
SCHEMBL16489738 0.93 RELA (0.78) RELATRPA1ACHEMAOAMAOB
SCHEMBL10015741 0.93 RELA (0.78) RELATRPA1ACHEMAOAMAOB
SCHEMBL7904563 0.93 RELA (0.78) RELATRPA1ACHEMAOAMAOB
SCHEMBL7904561 0.93 RELA (0.78) RELATRPA1ACHEMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130022902-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, IMAGE FORMING METHOD AND APPARATUS, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2013-01-24 US disclosed
EP-2549332-A1 Electrophotographic photoreceptor, image forming method and apparatus, and process cartridge Ricoh Company, Ltd. (JP) 2013-01-23 EP disclosed
US-20120321348-A1 IMAGE BEARING DRUM, IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-12-20 US disclosed
US-8273513-B2 Image forming apparatus, process cartridge, and image bearing member RICOH COMPANY, LIMITED (JP) 2012-09-25 US disclosed
US-20080227007-A1 Image forming apparatus and process cartridge RICOH COMPANY, LTD. 2008-09-18 US disclosed