Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 9/20 | 0.69 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.49 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.49 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.49 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1268305 | 1.00 | HTR2B (0.69) | HTR2BHTR1DHTR7HTR3AGABRA1 | |
| SCHEMBL1266690 | 0.86 | HTR2B (0.66) | HTR2BHTR1DHTR7HTR3AGABRA1 | |
| SCHEMBL1266688 | 0.86 | HTR2B (0.66) | HTR2BHTR1DHTR7HTR3AGABRA1 | |
| Aerugine SCHEMBL12468920 | 0.82 | HTR2B (1.00) | HTR2BHTR1DHTR7HTR3AHTR2C | |
| Aerugine SCHEMBL29926829 | 0.82 | HTR2B (1.00) | HTR2BHTR1DHTR7HTR3AHTR2C | |
| Aerugine SCHEMBL12468918 | 0.82 | HTR2B (1.00) | HTR2BHTR1DHTR7HTR3AHTR2C | |
| SCHEMBL26117247 | 0.78 | HTR2B (0.76) | HTR2BHTR1DHTR7HTR3AHTR2C | |
| SCHEMBL1686982 | 0.78 | HTR2B (0.76) | HTR2BHTR1DHTR7HTR3AHTR2C | |
| SCHEMBL30608416 | 0.78 | HTR2B (0.76) | HTR2BHTR1DHTR7HTR3AHTR2C | |
| SCHEMBL1534272 | 0.78 | HTR2B (0.76) | HTR2BHTR1DHTR7HTR3AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879886-B2 | such as N-benzyl-N-hydroxy-2-(3-hydoxypyridin-2-ene)-1,3-thiazolidine-4-carboxamide, used for reducing the population of Plasmodium in a human infested with Plasmodium protozoans and suffering from malaria | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20070232664-A1 | Iron binding agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
| US-7144904-B2 | desferrithiocin analogs used as siderophores, for treatment of malaria in humans | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20050245579-A1 | Iron binding agents | BERGERON RAYMOND J JR | 2005-11-03 | — | — | US | disclosed |
| US-6864270-B2 | Iron binding agents | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1488791-A2 | Antimalarial agents | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2004-12-22 | — | — | EP | disclosed |
| US-20030083349-A1 | Iron binding agents | UNIVERSITY OF FLORIDA (US) | 2003-05-01 | — | — | US | disclosed |
| EP-1143951-A2 | ANTIMALARIAL AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000016763-A2 | ANTIMALARIAL AGENTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232664-A1 | Iron binding agents | TFRC, SLC40A1, FECH | HTR2B 3804/4885HTR1D 4697/4885HTR7 4429/4885 |
| US-20050245579-A1 | Iron binding agents | TFRC, SLC40A1, FECH | HTR2B 3804/4885HTR1D 4697/4885HTR7 4429/4885 |
| US-20030083349-A1 | Iron binding agents | TFRC, SLC40A1, FECH | HTR2B 3804/4885HTR1D 4697/4885HTR7 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.