Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15372099 | 0.91 | TBK1 (0.30) | TBK1HSD17B10 | |
| SCHEMBL12682965 | 0.87 | KMT2A (0.39) | BACE1KMT2AUSP30 | |
| SCHEMBL12683240 | 0.86 | KMT2A (0.34) | BACE1KMT2AUSP30TBK1 | |
| SCHEMBL12683057 | 0.80 | USP30 (0.32) | USP30HSD17B10 | |
| SCHEMBL15372101 | 0.79 | HCRTR1 (0.36) | KMT2AHSD17B10 | |
| SCHEMBL15372103 | 0.78 | CNR1 (0.34) | KMT2AHSD17B10 | |
| SCHEMBL12683153 | 0.77 | HCRTR1 (0.35) | — | |
| SCHEMBL15372100 | 0.75 | — | — | |
| SCHEMBL15373642 | 0.74 | HDAC3 (0.40) | BACE1TBK1 | |
| SCHEMBL12683010 | 0.74 | PREP (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012050918-A2 | TRICYCLIC FUSED RING INHIBITORS OF HEPATITIS C | PRESIDIO PHARMACEUTICAL, INC. (US) | 2012-04-19 | — | — | WO | disclosed |