Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316713 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL14749721 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL11435600 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL16723870 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL3626142 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL11375880 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL2775487 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL8421741 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL21818217 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 | |
| SCHEMBL14725979 | 1.00 | PAOX (0.72) | PAOXALDH1A1ACHELMNASLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688737-B2 | Protease stabilized acylated insulin analogues | NOVO NORDISK A/S (DK) | 2017-06-27 | — | — | US | disclosed |
| US-20150210747-A1 | PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES | NOVO NORDISK AS (DK) | 2015-07-30 | — | — | US | disclosed |
| US-20140357838-A1 | N-Terminally Modified Insulin Derivatives | NOVO NORDISK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-20140357838-A1 | N-Terminally Modified Insulin Derivatives | NOVO NORDISK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-20140315797-A1 | Novel N-Terminally Modified Insulin Derivatives | NOVO NORDISK A/S (DK) | 2014-10-23 | — | — | US | disclosed |
| US-20140315797-A1 | Novel N-Terminally Modified Insulin Derivatives | NOVO NORDISK A/S (DK) | 2014-10-23 | — | — | US | disclosed |
| WO-2012049307-A2 | NOVEL N-TERMINALLY MODIFIED INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210747-A1 | PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES | IAPP, IDE, LIPE | PAOX 769/4885ALDH1A1 4398/4885ACHE 1502/4885 |
| US-20140357838-A1 | N-Terminally Modified Insulin Derivatives | IAPP, INSR, PTMS | PAOX 2818/4885ALDH1A1 4875/4885ACHE 4290/4885 |
| US-20140315797-A1 | Novel N-Terminally Modified Insulin Derivatives | IAPP, INSR, IRS1 | PAOX 1794/4885ALDH1A1 4878/4885ACHE 4591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.