Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12688903 | 0.86 | ALDH1A1 (0.40) | ALDH1A1KDM4CKMT2AMEN1L3MBTL1 | |
| SCHEMBL12544907 | 0.81 | MAPT (0.39) | MAPTNAMPTKMT2AMEN1PDE4B | |
| SCHEMBL12544905 | 0.81 | MAPT (0.39) | MAPTNAMPTKMT2AMEN1PDE4B | |
| SCHEMBL12688904 | 0.75 | FLT1 (0.56) | ALDH1A1KMT2AMEN1L3MBTL1NPC1 | |
| SCHEMBL6205946 | 0.75 | RAB9A (0.51) | NPC1RAB9ALCKCSF1RKDR | |
| SCHEMBL6205950 | 0.75 | RAB9A (0.51) | NPC1RAB9ALCKCSF1RKDR | |
| SCHEMBL12689053 | 0.74 | RAB9A (0.47) | ALDH1A1MAPTRXFP1KMT2AMEN1 | |
| SCHEMBL12688683 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL12688905 | 0.74 | KMT2A (0.54) | ALDH1A1KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL12689058 | 0.74 | CD38 (0.40) | ALDH1A1KMT2AMEN1L3MBTL1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245137-A1 | ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245137-A1 | ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | CACNA1I, CACNA1G, CACNA1A | ALDH1A1 588/4885MAPT 3524/4885KDM4C 3964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.