Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.74 |
| ▸ | TOP2A | P11388 | 1/20 | 0.74 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | STK17B | O94768 | 3/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261091 | 0.83 | TOP1 (0.75) | TOP1TOP2ALCKPRKACAMEN1 | |
| SCHEMBL4261090 | 0.83 | TOP1 (0.75) | TOP1TOP2ALCKPRKACAMEN1 | |
| SCHEMBL12694945 | 0.82 | TOP1 (0.74) | TOP1TOP2ASIRT1SIRT2SIRT5 | |
| SCHEMBL12694949 | 0.81 | STK17B (0.66) | PRKACAMEN1KMT2ASTK17BHDAC3 | |
| SCHEMBL4267528 | 0.78 | TOP1 (0.76) | TOP1TOP2ALCKPRKACAMEN1 | |
| SCHEMBL4267530 | 0.78 | TOP1 (0.76) | TOP1TOP2ALCKPRKACAMEN1 | |
| SCHEMBL1078524 | 0.77 | TOP1 (0.66) | TOP1TOP2AMEN1KMT2AALDH1A1 | |
| SCHEMBL5082831 | 0.72 | RAF1 (0.73) | RAF1EGFRIGF1RKDRPLK1 | |
| SCHEMBL4727806 | 0.72 | RAF1 (0.73) | RAF1EGFRIGF1RKDRPLK1 | |
| SCHEMBL30429323 | 0.72 | TOP1 (0.59) | TOP1TOP2AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |
| US-9567305-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2017-02-14 | — | — | US | disclosed |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-8669363-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-8669363-B2 | Quinoxaline compounds and derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2014-03-11 | — | — | US | disclosed |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | SOUTHERN METHODIST UNIVERSITY (US) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135494-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | TOP1 63/4885TOP2A 55/4885SIRT1 167/4885 |
| US-20120245352-A1 | Quinoxaline Compounds and Derivatives | CYP3A5, PDXK, QDPR | TOP1 63/4885TOP2A 55/4885SIRT1 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.