Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12696731 | 0.82 | TAAR1 (0.55) | TAAR1KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL12696741 | 0.72 | GAA (0.39) | HRH3TAAR1KDM4EALDH1A1HTT | |
| SCHEMBL12696765 | 0.72 | GPR119 (0.47) | HRH3DHFRME2ME1ME3 | |
| SCHEMBL12696767 | 0.70 | TAAR1 (0.39) | TAAR1KMT2AMEN1LMNAL3MBTL1 | |
| SCHEMBL3920532 | 0.69 | DHFR (0.48) | HRH3DHFRME2ME1ME3 | |
| SCHEMBL14650779 | 0.69 | UBE2T (0.51) | HRH3DHFRME2ME1ME3 | |
| SCHEMBL9366521 | 0.69 | HRH3 (0.65) | HRH3DHFRME2ME1ME3 | |
| SCHEMBL8931702 | 0.68 | KMT2A (0.51) | HRH3DHFRME2ME1ME3 | |
| SCHEMBL27837554 | 0.68 | UBE2T (0.50) | HRH3DHFRKMT2AMEN1HSD17B10 | |
| SCHEMBL16473496 | 0.67 | GPR119 (0.64) | HRH3ME2ME1ME3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012126984-A1 | NOVEL SUBSTITUTED TRIAZOLYL PIPERAZINE AND TRIAZOLYL PIPERIDINE DERIVATIVES AS GAMMA SECRETASE MODULATORS | Janssen Pharmaceuticals, Inc. (US) | 2012-09-27 | — | — | WO | disclosed |