Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | ME2 | P23368 | 2/20 | 0.45 |
| ▸ | ME1 | P48163 | 2/20 | 0.45 |
| ▸ | ME3 | Q16798 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16473496 | 0.85 | GPR119 (0.64) | GPR119HRH3ME2ME1ME3 | |
| SCHEMBL7932466 | 0.84 | PANK3 (0.46) | GPR119HRH3PPARADHFRHPGD | |
| SCHEMBL19446825 | 0.76 | MAP4K4 (0.39) | GPR119ME2ME1ME3HPGD | |
| SCHEMBL22644657 | 0.75 | GPR119 (0.64) | GPR119ME2ME1ME3HPGD | |
| SCHEMBL14650779 | 0.74 | UBE2T (0.51) | HRH3ME2ME1ME3PPARA | |
| SCHEMBL21241225 | 0.73 | GRIN2D (0.42) | GPR119HSD17B10HPGDNPSR1LMNA | |
| SCHEMBL27837554 | 0.73 | UBE2T (0.50) | HRH3DHFRHSD17B10NPSR1LMNA | |
| SCHEMBL22581906 | 0.72 | GPR119 (0.60) | GPR119HPGDSMN1; SMN2DDB1CRBN | |
| SCHEMBL30620934 | 0.72 | GPR119 (0.60) | GPR119DDB1CRBNRETCKS1B | |
| SCHEMBL12696744 | 0.72 | HRH3 (0.44) | HRH3ME2ME1ME3PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012126984-A1 | NOVEL SUBSTITUTED TRIAZOLYL PIPERAZINE AND TRIAZOLYL PIPERIDINE DERIVATIVES AS GAMMA SECRETASE MODULATORS | Janssen Pharmaceuticals, Inc. (US) | 2012-09-27 | — | — | WO | disclosed |