Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23107400 | 1.00 | CHRNB2 (0.55) | CHRNB2CHRNA4MAP3K12MAP3K7SOS1 | |
| SCHEMBL23104674 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4MAP3K12PIK3CAMTOR | |
| SCHEMBL23707037 | 0.82 | MAP3K12 (0.43) | CHRNB2CHRNA4MAP3K12MAP3K7PIK3CA | |
| SCHEMBL23108850 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4MAP3K12PIK3CAMTOR | |
| SCHEMBL23089503 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4MAP3K12PIK3CAMTOR | |
| SCHEMBL22650441 | 0.82 | CHRNB2 (0.55) | CHRNB2CHRNA4MAP3K12PIK3CAMTOR | |
| SCHEMBL25147088 | 0.82 | MAP3K12 (0.40) | CHRNB2CHRNA4MAP3K12MAP3K7SOS1 | |
| SCHEMBL23103403 | 0.82 | MAP3K12 (0.40) | CHRNB2CHRNA4MAP3K12MAP3K7SOS1 | |
| SCHEMBL23114429 | 0.82 | SOS1 (0.41) | MAP3K12SOS1PIK3CAMTORIDH1 | |
| SCHEMBL23114379 | 0.82 | SOS1 (0.41) | MAP3K12SOS1PIK3CAMTORIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021259208-A1 | TYK-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-12-30 | — | — | WO | disclosed |
| US-11034694-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20120245136-A1 | CHROMAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245136-A1 | CHROMAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | KCNJ2, KCNJ1, KCNC1 | CHRNB2 202/4885CHRNA4 142/4885MAP3K12 1213/4885 |
| US-11034694-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, IP6K1, PDXK | CHRNB2 1299/4885CHRNA4 2353/4885MAP3K12 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.