Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.57 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12697368 | 0.96 | FAAH (0.61) | FAAHCNR2HPGDLIPGLMNA | |
| SCHEMBL16977703 | 0.94 | LIPG (0.55) | FAAHCNR2HPGDLIPGLMNA | |
| SCHEMBL12697416 | 0.85 | CNR2 (0.56) | FAAHCNR2HPGDLMNAMAPT | |
| SCHEMBL12697379 | 0.83 | CNR2 (0.65) | FAAHCNR2HPGDLMNAMAPT | |
| SCHEMBL15708143 | 0.81 | LMNA (0.70) | HPGDLMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL12697381 | 0.81 | EGLN1 (0.59) | FAAHCNR2HPGDLMNAMAPT | |
| SCHEMBL8981479 | 0.81 | CNR2 (0.55) | FAAHCNR2HPGDLMNAMAPT | |
| SCHEMBL8981503 | 0.80 | CNR2 (0.54) | FAAHCNR2HPGDMAPTGAA | |
| SCHEMBL12697314 | 0.80 | KMT2A (0.59) | HPGDLIPGLMNAMAPTL3MBTL1 | |
| SCHEMBL8981509 | 0.79 | CNR2 (0.53) | FAAHCNR2HPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-08-06 | — | — | US | disclosed |
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (US) | 2014-05-22 | — | — | US | disclosed |
| WO-2012106534-A2 | HIV INTEGRASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142137-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | FAAH 3688/4885CNR2 4787/4885HPGD 1507/4885 |
| US-20150218120-A1 | HIV INTEGRASE INHIBITORS | IMPDH1, TYMP, IMPA1 | FAAH 3688/4885CNR2 4787/4885HPGD 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.