Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 3/20 | 0.52 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 5/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12698697 | 1.00 | GHSR (0.52) | GHSRSLC6A7SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL13825034 | 0.95 | SMN1; SMN2 (0.53) | GHSRSLC6A7SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL12698700 | 0.95 | SMN1; SMN2 (0.53) | GHSRSLC6A7SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL12761089 | 0.83 | L3MBTL1 (0.57) | GHSRSLC6A7SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL20192340 | 0.83 | L3MBTL1 (0.73) | SLC6A7SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL26814604 | 0.80 | L3MBTL1 (0.54) | GHSRSLC6A7SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL1946155 | 0.77 | SETD7 (0.52) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL20750605 | 0.76 | L3MBTL1 (0.51) | GHSRL3MBTL1HTT | |
| SCHEMBL10261766 | 0.76 | PKLR (0.62) | — | |
| SCHEMBL10267625 | 0.76 | PKLR (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151452-A1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS, INC (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012092442-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2012-07-05 | — | — | WO | disclosed |