Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.59 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.59 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12700261 | 0.85 | TP53 (0.75) | RAB9ANPC1SMN1; SMN2FFAR1TP53 | |
| SCHEMBL12698839 | 0.83 | NR1H4 (0.64) | RAB9ANPC1FFAR1TP53MEN1 | |
| SCHEMBL17660217 | 0.82 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2CASP3SENP8 | |
| SCHEMBL23844170 | 0.82 | NPC1 (0.76) | RAB9ANPC1SMN1; SMN2CASP3SENP8 | |
| SCHEMBL2563194 | 0.80 | NPC1 (0.68) | RAB9ANPC1SMN1; SMN2CASP3SENP8 | |
| SCHEMBL12218356 | 0.79 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2CASP3SENP8 | |
| SCHEMBL12218052 | 0.79 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2CASP3SENP8 | |
| SCHEMBL18132528 | 0.79 | ROCK2 (0.63) | SMN1; SMN2FFAR1TP53MEN1KMT2A | |
| SCHEMBL12218013 | 0.78 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2CASP3SENP8 | |
| SCHEMBL12218058 | 0.78 | SMN1; SMN2 (1.00) | RAB9ANPC1SMN1; SMN2CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199918-B2 | Small molecule inhibitors of AGBL2 | GEORGETOWN UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |
| US-9199918-B2 | Small molecule inhibitors of AGBL2 | GEORGETOWN UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |
| WO-2012112567-A1 | SMALL MOLECULE INHIBITORS OF AGBL2 | GEORGETOWN UNIVERSITY (US) | 2012-08-23 | — | — | WO | disclosed |