SCHEMBL12700581

SCHEMBL12700581

C1=CCCC(N(c2ccc(Nc3ccccc3)cc2)c2cccc3ccccc23)=C1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
HSD17B10 Q99714 3/20 0.36
CYP3A4 P08684 2/20 0.36
HPGD P15428 2/20 0.36
ALOX15 P16050 2/20 0.36
TSHR P16473 2/20 0.36
TP53 P04637 1/20 0.36
CDC25B P30305 1/20 0.36
ATM Q13315 1/20 0.36
SIGMAR1 Q99720 1/20 0.33
KDM1A O60341 4/20 0.32
NPY5R Q15761 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
ALOX12 P18054 1/20 0.31
PTGS1 P23219 1/20 0.31
SLC6A2 P23975 1/20 0.31
MAPK1 P28482 1/20 0.31
PTGS2 P35354 1/20 0.31
HTR2B P41595 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13177203 0.91 ALDH1A1 (0.40) ALDH1A1HSD17B10CYP3A4HPGD
SCHEMBL21236751 0.89 SIGMAR1 (0.38) ALDH1A1CYP3A4TSHRSIGMAR1L3MBTL1
SCHEMBL13821963 0.88 SIGMAR1 (0.35) ALDH1A1CYP3A4SIGMAR1L3MBTL1TDP1
SCHEMBL12557773 0.87 L3MBTL1 (0.40) ALDH1A1HPGDATMSIGMAR1L3MBTL1
SCHEMBL18872362 0.85 SIGMAR1 (0.34) SIGMAR1
SCHEMBL10029773 0.85 SIGMAR1 (0.34) SIGMAR1
SCHEMBL18900780 0.84 SIGMAR1 (0.34) ALDH1A1SIGMAR1SLC6A2
SCHEMBL16775507 0.84 SIGMAR1 (0.35) SIGMAR1
SCHEMBL12700576 0.83 ALDH1A1 (0.39) ALDH1A1HSD17B10CYP3A4HPGDALOX15
SCHEMBL13190815 0.82 SIGMAR1 (0.33) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0891121-B1 ORGANIC ELECTROLUMINESCENT ELEMENTS TDK CORP (JP) 2012-09-26 EP disclosed