Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12701209 | 0.91 | MAPK1 (0.40) | MAPK1NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL27651716 | 0.84 | HDAC4 (0.47) | MAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23198268 | 0.81 | AGTR2 (0.44) | MAPK1NOTUMAGTR2MAPTALDH1A1 | |
| SCHEMBL20141927 | 0.81 | AGTR2 (0.44) | MAPK1NOTUMAGTR2MAPTALDH1A1 | |
| SCHEMBL20141914 | 0.81 | AGTR2 (0.44) | MAPK1NOTUMAGTR2MAPTALDH1A1 | |
| SCHEMBL5702089 | 0.77 | NOTUM (0.49) | NOTUMAGTR2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL5702158 | 0.77 | NOTUM (0.49) | NOTUMAGTR2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL25154724 | 0.76 | FFAR1 (0.49) | MAPK1 | |
| SCHEMBL11453714 | 0.76 | SMN1; SMN2 (0.47) | MAPK1MAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5633128 | 0.75 | MAPK1 (0.61) | MAPK1HTR2AHTR2CHTR2BCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092703-A1 | P2X4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO., LTD. (JP) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092703-A1 | P2X4 RECEPTOR ANTAGONIST | P2RX3, P2RX1, P2RX4 | MAPK1 761/4885NOTUM 4112/4885AGTR2 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.