Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270970 | 1.00 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL1270933 | 1.00 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL4768007 | 0.92 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL12290332 | 0.90 | ALDH1A1 (0.46) | KMT2ACYP1A2SIGMAR1ALDH1A1GAA | |
| SCHEMBL12080377 | 0.78 | KMT2A (0.51) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL22932479 | 0.78 | KMT2A (0.51) | NPC1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL5540914 | 0.77 | HTR2A (0.40) | MEN1KMT2AKDM4ELMNAL3MBTL1 | |
| SCHEMBL25292448 | 0.76 | SIGMAR1 (0.51) | NPC1RAB9AKMT2ASIGMAR1ALDH1A1 | |
| SCHEMBL2621329 | 0.76 | SIGMAR1 (0.44) | KMT2ASIGMAR1ALDH1A1GAAMAPT | |
| SCHEMBL10168839 | 0.76 | ALDH1A1 (0.45) | SIGMAR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207186-B2 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase MET | MERCK SHARP & DOHME CORP. (US) | 2012-06-26 | — | — | US | disclosed |
| US-8207186-B2 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase MET | MERCK SHARP & DOHME CORP. (US) | 2012-06-26 | — | — | US | disclosed |
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |
| EP-1896422-B1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2011-08-17 | — | — | EP | disclosed |
| EP-1896422-B1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2011-08-17 | — | — | EP | disclosed |
| US-7893081-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893081-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-7893081-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090197908-A1 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met | MERCK SHARP & DOHME LLC | 2009-08-06 | — | — | US | disclosed |
| US-20090197908-A1 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met | MERCK SHARP & DOHME LLC | 2009-08-06 | — | — | US | disclosed |
| US-20090182002-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME LLC | 2009-07-16 | — | — | US | disclosed |
| US-20090182002-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME LLC | 2009-07-16 | — | — | US | disclosed |
| US-20090182002-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME LLC | 2009-07-16 | — | — | US | disclosed |
| US-7550478-B2 | Tyrosine kinase inhibitors | MERCK & CO. INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550478-B2 | Tyrosine kinase inhibitors | MERCK & CO. INC. (US) | 2009-06-23 | — | — | US | disclosed |
| CN-101203495-A | Benzocycloheptapyridine compounds as inhibitors of receptor tyrosine kinase MET | MERCK & CO INC (US) | 2008-06-18 | — | — | CN | disclosed |
| WO-2007002254-A2 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002258-A2 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182002-A1 | Tyrosine kinase inhibitors | JAK1, JAK2, LCK | NPC1 3932/4885RAB9A 3462/4885MEN1 1826/4885 |
| US-20090197908-A1 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met | MET, RET, ERBB2 | NPC1 1512/4885RAB9A 2745/4885MEN1 2383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.