Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627801 | 0.85 | LMNA (0.50) | NPC1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL11839455 | 0.77 | RXFP1 (0.67) | RXFP1NPC1RAB9AKMT2ANT5E | |
| SCHEMBL13383267 | 0.75 | AURKA (0.57) | RXFP1NPC1RAB9AKMT2ANT5E | |
| SCHEMBL1270828 | 0.73 | KMT2A (0.46) | RXFP1NPC1RAB9AKMT2ANT5E | |
| SCHEMBL1225985 | 0.73 | GDA (0.36) | RAB9AALDH1A1SMN1; SMN2DYRK1A | |
| SCHEMBL16639133 | 0.72 | GAA (0.51) | NPC1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL5344725 | 0.71 | P2RX3 (0.48) | NPC1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL609453 | 0.71 | LMNA (0.48) | NPC1RAB9AKMT2AHTTSMN1; SMN2 | |
| SCHEMBL26122012 | 0.71 | LMNA (0.48) | NPC1RAB9AKMT2AHTTSMN1; SMN2 | |
| SCHEMBL2221557 | 0.69 | ADORA3 (0.41) | NPC1RAB9AKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862686-B2 | N1-sulfonyl-5-fluoropyrimidinone derivatives | ADAMA MAKHTESHIM LTD. (IL) | 2018-01-09 | — | — | US | disclosed |
| US-9862686-B2 | N1-sulfonyl-5-fluoropyrimidinone derivatives | ADAMA MAKHTESHIM LTD. (IL) | 2018-01-09 | — | — | US | disclosed |
| US-20150191436-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-07-09 | — | — | US | disclosed |
| US-20150191436-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-07-09 | — | — | US | disclosed |
| US-20150191436-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-07-09 | — | — | US | disclosed |
| US-9006259-B2 | N1-sulfonyl-5-fluoropyrimidinone derivatives | DOW AGROSCIENCES LLC (US) | 2015-04-14 | — | — | US | disclosed |
| CN-102574831-B | N1-sulfonyl-5-fluoropyrimidinone derivatives | DOW AGROSCIENCES LLC | 2014-12-10 | — | — | CN | disclosed |
| EP-2462134-B1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2014-05-07 | — | — | EP | disclosed |
| EP-2462134-B1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2014-05-07 | — | — | EP | disclosed |
| EP-2462134-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | Dow AgroSciences LLC (US) | 2012-06-13 | — | — | EP | disclosed |
| WO-2011017547-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2011017547-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20110034493-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191436-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, SULT1E1, CYP1A1 | RXFP1 4356/4885NPC1 911/4885RAB9A 764/4885 |
| US-20110034493-A1 | N1-SULFONYL-5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, SULT1E1, CYP1A1 | RXFP1 4356/4885NPC1 911/4885RAB9A 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.