SCHEMBL1271007

SCHEMBL1271007

CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(=O)C(N)CCC(N)=O

nearest known ligand 0.62

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSL P07711 5/20 0.62
CTSS P25774 1/20 0.62
CTSK P43235 1/20 0.62
MAPT P10636 2/20 0.55
TP53 P04637 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.54
ACE P12821 1/20 0.53
TACR1 P25103 2/20 0.52
CCKBR P32239 5/20 0.50
BCHE P06276 1/20 0.49
ACHE P22303 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1271407 0.93 CTSL (0.61) CTSLCTSSCTSKMAPTTP53
SCHEMBL1270433 0.86 CTSL (0.57) CTSLCTSSCTSKMAPTTP53
SCHEMBL1270426 0.83 KDM4E (0.53) CTSLMAPTBCHEACHE
SCHEMBL30643020 0.82 CTSL (0.67) CTSLCTSSCTSKMAPTTP53
SCHEMBL29419170 0.82 CTSL (0.77) CTSLCTSSCTSKMAPTTP53
SCHEMBL21286953 0.82 CTSL (0.77) CTSLCTSSCTSKMAPTTP53
SCHEMBL30375072 0.82 CTSL (0.80) CTSLCTSSCTSKMAPTTP53
SCHEMBL21269082 0.82 CTSL (0.77) CTSLCTSSCTSKMAPTTP53
SCHEMBL31360963 0.81 CTSL (0.63) CTSLCTSSCTSKMAPTTP53
SCHEMBL645235 0.81 ACE (0.66) CTSLCTSSCTSKMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110038885-A1 CHEMOKINE ANALOGS IPSEN PHARMA S.A.S. (FR) 2011-02-17 US claimed
JP-2010534652-A 2010-11-11 JP claimed
EP-2182973-A1 CHEMOKINE ANALOGS IPSEN PHARMA S.A.S. (FR) 2010-05-12 EP claimed
WO-2009017620-A1 CHEMOKINE ANALOGS IPSEN PHARMA S.A.S. (FR) 2009-02-05 WO claimed
US-20110038885-A1 CHEMOKINE ANALOGS IPSEN PHARMA S.A.S. (FR) 2011-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110038885-A1 CHEMOKINE ANALOGS CCL11, CCL5, CCL2 CTSL 140/4885CTSS 1067/4885CTSK 980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.