Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.79 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.79 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693479 | 0.89 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL127152 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL7299526 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10695208 | 0.89 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Denbufylline SCHEMBL11044404 | 0.88 | PDE4A (0.97) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10872056 | 0.87 | PDE4A (0.95) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL1946890 | 0.87 | POLB (0.67) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL3615415 | 0.86 | ALDH1A1 (0.63) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7323464 | 0.86 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10694108 | 0.85 | PDE4A (0.91) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260127-A2 | Xanthine derivatives, their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-03-16 | — | — | EP | disclosed |